منابع مشابه
Ischemic postconditioning in pigs: no causal role for RISK activation.
Ischemic postconditioning (IPoC) reduces infarct size following ischemia/reperfusion. Whether or not phosphorylation of RISK (reperfusion injury salvage kinases) (AKT, ERK1/2, P70S6K, GSK3beta) is causal for protection by IPoC is controversial. We therefore studied the impact of RISK on IPoC in anesthetized pigs subjected to 90 minutes of left anterior descending coronary artery hypoperfusion a...
متن کاملMitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion.
RATIONALE Timely restoration of coronary blood flow is the only way to salvage myocardium from infarction, but reperfusion per se brings on additional injury. Such reperfusion injury and the resulting size of myocardial infarction is attenuated by ischemic postconditioning, ie, the repeated brief interruption of coronary blood flow during early reperfusion. The signal transduction of ischemic p...
متن کاملIschemic postconditioning: a clinical perspective
Acute myocardial infarction is a major cause of death and heart failure in western society [1]. Introduction of reperfusion therapy in terms of thrombolysis and primary percutaneous coronary intervention (PPCI) has lead to a significant decreases in morbidity and mortality [2]. Today, PPCI is the recommended therapy for patients with ST-segment elevation myocardial infarction (STEMI). However, ...
متن کاملSurvival kinases in ischemic preconditioning and postconditioning.
Despite nearly twenty years of research into the field of ischemic preconditioning, the actual mechanism of protection remains unclear. However, much progress has been made in elucidating the signal transduction pathways that convey the extracellular signal initiated by the preconditioning stimulus to the intracellular targets of cardioprotection, with many of these pathways involving the activ...
متن کاملIschemic Postconditioning Attenuates Bilateral Renal Ischemia-Induced Cognitive Impairments
Background and aim: Acute kidney injury (AKI) is a frequent complication of kidney failure with high mortality which leads to brain dysfunction. The aim of this study was to investigate the possible protective effect of ischemic postconditioning (IPo) against brain dysfunction induced by bilateral renal ischemia (BRI). Materials and methods: Male Wistar rats underwent BRI, sham or IPo surgery ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2009
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.108.186429